GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs9902453 | 1 | rs62070312 | chr17:28438877 | EFCAB5 | chr17:28256874-28435469:+ | 0.4 | 4.97 | 6.82E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs10935120 | 1 | rs62269547 | chr3:134214042 | ANAPC13 | chr3:134196547-134204865:- | 0.46 | 7.06 | 3.0E-9 | Height |
| UVM | cis | rs10935120 | 1 | rs62271513 | chr3:134298412 | ANAPC13 | chr3:134196547-134204865:- | -0.45 | -6.73 | 1.03E-8 | Height |
| UVM | cis | rs10935120 | 1 | rs62271514 | chr3:134298554 | ANAPC13 | chr3:134196547-134204865:- | -0.45 | -6.73 | 1.03E-8 | Height |
| UVM | cis | rs10935120 | 1 | rs62271515 | chr3:134300507 | ANAPC13 | chr3:134196547-134204865:- | 0.45 | 6.73 | 1.03E-8 | Height |
| UVM | cis | rs568617 | 1 | rs641018 | chr11:65655393 | SNX32 | chr11:65601410-65621170:+ | 0.63 | 5.51 | 9.72E-7 | Crohn's disease |
| UVM | cis | rs1411478 | 1 | rs6425657 | chr1:180956905 | STX6 | chr1:180913175-180992046:- | -0.58 | -5.69 | 5.07E-7 | Progressive supranuclear palsy |
| UVM | cis | rs1411478 | 1 | rs6425658 | chr1:180956985 | STX6 | chr1:180913175-180992046:- | -0.58 | -5.69 | 5.07E-7 | Progressive supranuclear palsy |
| UVM | cis | rs4660306 | 1 | rs6429567 | chr1:45956700 | CCDC163P | chr1:45960581-45965646:- | -0.83 | -9.05 | 1.73E-12 | Homocysteine levels |
| UVM | cis | rs4660306 | 1 | rs6429569 | chr1:46001330 | CCDC163P | chr1:45960581-45965646:- | -0.75 | -6.76 | 9.48E-9 | Homocysteine levels |
| UVM | cis | rs13014235 | 1 | rs6435079 | chr2:202200331 | ALS2CR12 | chr2:202153148-202222101:- | -0.45 | -4.65 | 2.12E-5 | Basal cell carcinoma |
| UVM | cis | rs13014235 | 1 | rs6435081 | chr2:202220623 | ALS2CR12 | chr2:202153148-202222101:- | -0.46 | -4.69 | 1.82E-5 | Basal cell carcinoma |
| UVM | cis | rs10935120 | 1 | rs6439484 | chr3:134249899 | ANAPC13 | chr3:134196547-134204865:- | 0.46 | 6.87 | 6.1E-9 | Height |
| UVM | cis | rs10935120 | 1 | rs6439487 | chr3:134260860 | ANAPC13 | chr3:134196547-134204865:- | 0.46 | 6.87 | 6.1E-9 | Height |
| UVM | cis | rs9876781 | 1 | rs6442117 | chr3:48419897 | TREX1 | chr3:48501186-48509043:+ | 0.4 | 4.97 | 6.82E-6 | Longevity |